A trial of implanted spinal-cord stimulation in 91 people with severe, treatment-resistant painful diabetic neuropathy reported a six-month increase in lower-calf skin nerve-fiber density: 0.58 fibers/mm on average, compared with a decrease of 0.07 with usual care.
Why a neuropathy exam checks more than pain
Someone can lose protective feeling in the feet without noticing pain.
Diabetic neuropathy can matter beyond the feet
In a study of 794 people with diabetic neuropathy, worse nerve-conduction findings were associated with poorer measures of autonomic function related to heart rate.
Laser research for neuropathy: why the device and diagnosis matter
A small sham-controlled trial found a symptom benefit with a particular dual-wavelength laser in painful diabetic neuropathy.
When numbness is not explained by diabetes alone
Two clinical reviews make an important point: the pattern of symptoms matters.
Can cooling during chemotherapy prevent numbness?
A review of studies in breast cancer found that supervised cooling during paclitaxel treatment was associated with a lower risk of at least moderate neuropathy.
Protecting nerves before chemotherapy is different from repairing them afterward
Researchers found that psilocybin given before certain chemotherapy drugs protected sensory nerves in mice.
Numb feet after chemotherapy: why ask about near-falls?
A review of 11 observational studies estimated that about one in four people studied with chemotherapy-related neuropathy reported a fall.
Can a skin biopsy show that small nerve fibers are changing?
A small, industry-developed phase 2 trial of topical pirenzepine in people with type 2 diabetes found a change in skin nerve-fiber density after 24 weeks at the higher dose.